Aquaporin-4, also known as AQP4, is a water channel protein encoded by the AQP4 gene in humans. AQP4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. Only limited aquaporins are found within the CNS: AQP1, 3, 4, 5, 8, 9, and 11, but only AQP1, 4, and 9 are exclusively found in the brain and spinal cord. Focusing on AQP4, which has the most water channels in the CNS, are specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. Aquaporin-4 was first discovered in 1986, it was the first evidence for the existence of water transport channels.
Abbkine Aquaporin 4 Monoclonal Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The isotype is Mouse IgG1. The antibody is suitable for WB, IF and staining Aquaporin 4 in IHC using paraffin embedded sections. It can react with Human, Mouse and Rat. Abbkine suggested optimal working dilutions should be determined experimentally by the investigator.
Immunohistochemical analysis of Human liver cancer tissue, labelling Aquaporin 4 with Abbkine Aquaporin 4 Monoclonal Antibody , diluted 1/200. Shows strong membranous staining of tubular epithelial cells. Finally, the customer service was superb. This was especially appreciated given that I am in Japan and they are in China.