Bioresearch Weekly Archives - Biotech Advisers

Structural basis of ubiquitin modification by the Legionella effector SdeA

13/07/2018 david.yang 200 Views 0 Comments ANKRD16, Cortical direction selectivity, cortical networks, LRRC8 family, SdeA

Content introduction: Pyramidal cell regulation of interneuron survival sculpts cortical networks Cortical direction selectivity emerges at convergence of thalamic synapses

Bioresearch Weekly

Multiplexed precision genome editing with trackable genomic barcodes in yeast

06/07/201803/07/2018 david.yang 99 Views 0 Comments cellular barcodes (MAGESTIC), gene silencing, large genetic variant libraries, large-scale genome-wide analysis, single-nucleotide precision

Content introduction: High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast Multiplexed precision genome editing

Bioresearch Weekly

Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model

29/06/201803/07/2018 david.yang 80 Views 0 Comments aggressive early-stage mycosis fungoides, kinase Plk1, spinal grafting, Valvular heart disease, viral bronchiolitis

Content introduction: Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep model Survival

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Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury

22/06/201803/07/2018 david.yang 112 Views 0 Comments Aneuploidy, Cancer Genome Atlas, Large-Scale Clonal Analysis, lncRNA Epigenetic Landscape Analysis, Reserve Stem Cells

Content introduction： A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an

Bioresearch Weekly

Renewing Felsenstein’s phylogenetic bootstrap in the era of big data

15/06/201803/07/2018 david.yang 200 Views 0 Comments epithelial-to-mesenchymal transition (EMT), Felsenstein’s phylogenetic bootstrap, isotope 229Th, liver transplantation, SAMHD1

Content introduction： A randomized trial of normothermic preservation in liver transplantation SAMHD1 acts at stalled replication forks to prevent interferon

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An in vivo model of functional and vascularized human brain organoids

28/05/201825/05/2018 david.yang 159 Views 0 Comments Batch effects, CRISPR–Cas9-induced genetic scars, DNA methylation profiles, Metabolomics activity screening, model human brain

Content introduction： An in vivo model of functional and vascularized human brain organoids Highly scalable generation of DNA methylation profiles

Bioresearch Weekly

A heterologous expression platform for the discovery of fungal natural products

26/04/201826/04/2018 david.yang 238 Views 0 Comments breast cancer, CSF1, Hex, MDM2, MDMX, voltage-gated sodium channels

Content introduction： Hex: A heterologous expression platform for the discovery of fungal natural products Differential expression of voltage-gated sodium channels

Bioresearch Weekly

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

30/03/2018 david.yang 219 Views 0 Comments BRD4 Inhibition, Carcinoma-associated fibroblasts (CAF), DCPS, Fc Effector Function, PKM1

1. PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth Expression of PKM2, which diverts glucose-derived carbon from catabolic

Bioresearch Weekly

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

23/03/2018 david.yang 239 Views 0 Comments block BRCA1 repair, central nervous system tumours, Epigenetic reprogramming, human gut bacteria, LHPP

1. The protein histidine phosphatase LHPP is a tumour suppressor. Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized

Bioresearch Weekly

Nanopore sequencing and assembly of a human genome with ultra-long reads

16/03/2018 david.yang 317 Views 0 Comments a three-dimensional view of gene variation, CAR-T cells, DNA data storage, DNA nanorobot, Nanopore sequencing

1. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

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