Bioresearch Weekly Archives - Biotech Advisers

A heterologous expression platform for the discovery of fungal natural products

26/04/201826/04/2018 david.yang 170 Views 0 Comments breast cancer, CSF1, Hex, MDM2, MDMX, voltage-gated sodium channels

Content introduction： Hex: A heterologous expression platform for the discovery of fungal natural products Differential expression of voltage-gated sodium channels

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Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

30/03/2018 david.yang 176 Views 0 Comments BRD4 Inhibition, Carcinoma-associated fibroblasts (CAF), DCPS, Fc Effector Function, PKM1

1. PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth Expression of PKM2, which diverts glucose-derived carbon from catabolic

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Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

23/03/2018 david.yang 195 Views 0 Comments block BRCA1 repair, central nervous system tumours, Epigenetic reprogramming, human gut bacteria, LHPP

1. The protein histidine phosphatase LHPP is a tumour suppressor. Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized

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Nanopore sequencing and assembly of a human genome with ultra-long reads

16/03/2018 david.yang 208 Views 0 Comments a three-dimensional view of gene variation, CAR-T cells, DNA data storage, DNA nanorobot, Nanopore sequencing

1. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

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A PET imaging approach for determining EGFR mutation status for improved lung cancer patient management

09/03/2018 david.yang 170 Views 0 Comments acute myeloid leukemia, blood pressure monitoring, lung cancer patient, pregnancy, Systemic sclerosis

1. Malaria in pregnancy alters l-arginine bioavailability and placental vascular development. Reducing adverse birth outcomes due to malaria in pregnancy

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Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

02/03/201802/03/2018 david.yang 222 Views 0 Comments c-Myc Transcription Factor, DCPS, Enhancing N-Glycan Branching, High-Dimensional Single-Cell Mapping, STAT6

1. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. To identify novel targets for

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Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signaling

29/01/2018 david.yang 115 Views 0 Comments endocrine FGF signaling, EZH1, intercellular enzymatic labeling, Kaposi’s sarcoma-associated herpesvirus (KSHV), Relapsed acute lymphoblastic leukaemia (ALL)

1. Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Relapsed acute lymphoblastic leukaemia (ALL) is associated with resistance to

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Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus

19/01/201819/01/2018 david.yang 149 Views 0 Comments ATP-binding cassette (ABC) transporter, combinatorial genetic screens, hybrid inviability, leucine-rich repeat receptor kinases (LRR-RKs), viral infection of single cells

1. Orthologous CRISPR–Cas9 enzymes for combinatorial genetic screens. Combinatorial genetic screening using CRISPR–Cas9 is a useful approach to uncover redundant

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β-Arrestin–biased β-adrenergic signaling promotes extinction learning of cocaine reward memory

12/01/2018 david.yang 166 Views 0 Comments ATM, Immune checkpoint inhibitors, oncolytic virotherapy, Transferrin receptor 1, β-Arrestin–biased

1. Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. Immune checkpoint inhibitors, including

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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas

05/01/2018 david.yang 180 Views 0 Comments Elevated Mitochondrial Mass, Injury Induces, p53 Super-tumor Suppressor, SETD8 Inhibition, Stress-Activated NRF2-MDM2

1. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (PanIN1)

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