CK17 plays a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. It may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial “stem cells”. And act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. CK17 required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Abbkine CK17 Monoclonal Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The application in WB, IF, IHC-P and IP experiments had been well validated. This antibody can be used to detect endogenous CK17 protein in the sample of Human. According to your own experimental conditions, optimal working dilutions should be explored.
Immunofluorescence analysis of human breast tissue by using Abbkine CK17 Monoclonal Antibody. The antibody was diluted at 1:200. The fluorescence signal produced is strong and the results are accord with my experiment expectation. As a faithful funs of Abbkine, I always trust this brand. This antibody also didn’t let me down. Good specificity, reliable quality and cheaper price, it deserved to be recommended to more researchers.