HP-1α encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Abbkine HP-1α Mouse Monoclonal Antibody derives from mouse ascites after the stimulation of HP-1α recombinant protein. The antibody was affinity-purified by affinity-chromatography. Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-2000, IHC-p: 1:50-2000. This antibody can be applied to WB, IHC-p, IF and it can react with endogenous HP-1α protein of human, mouse, rat.
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