The Nobel Prize in Physiology or Medicine 2000 was awarded jointly to Arvid Carlsson, Paul Greengard and Eric R. Kandel “for their discoveries concerning signal transduction in the nervous system.”
|Nobelist||Born||Died||Affiliation at the time of the award|
|Arvid Carlsson||25 January 1923, Uppsala, Sweden||29 June 2018, Gothenburg, Sweden||Göteborg University, Gothenburg, Sweden|
|Paul Greengard||11 December 1925, New York, NY, USA||Rockefeller University, New York, NY, USA|
|Eric R. Kandel||7 November 1929, Vienna, Austria||Columbia University, New York, NY, USA|
In the human brain there are more than hundred billion nerve cells. They are connected to each other through an infinitely complex network of nerve processes. The message from one nerve cell to another is transmitted through different chemical transmitters. The signal transduction takes place in special points of contact, called synapses. A nerve cell can have thousands of such contacts with other nerve cells.
The three Nobel Laureates in Physiology or Medicine have made pioneering discoveries concerning one type of signal transduction between nerve cells, referred to as slow synaptic transmission. These discoveries have been crucial for an understanding of the normal function of the brain and how disturbances in this signal transduction can give rise to neurological and psychiatric diseases. These findings have resulted in the development of new drugs.
More details, please click The Nobel Prize in Physiology or Medicine 2000.