Abbkine Scientific is a renowned research and life science company, offering several research solutions to investigators and researchers across the globe. The brand has grown to become one of the trusted names in the field of life science research, thanks to its innovative research tools and products. The Chinese based scientific research company recently announced the official launch of its new product – the IDE Monoclonal Antibody.
The IDE Monoclonal Antibody also referred to as IDE antibody or Insulin-degrading enzyme antibody follows the trend of premium quality and efficiency the Abbkine brand is known for. The Insulin protease antibody like its counterparts from the scientific research giant is designed to simplify and enhance research processes, consequently helping to achieve more results.
The IDE Monoclonal Antibody has been scrutinized by several people, with scientific researchers and investigators particularly reviewing the product. A more comprehensive review of the newly-launched IDE Monoclonal Antibody is done below.
Background of IDE Monoclonal Antibody
IDE encodes a zinc metallopeptidase, which degrades intracellular insulin, subsequently terminating insulin activity. It also participates in intercellular peptide signaling by degrading diverse peptides like glucagon, amylin, bradykinin, and kallidin. The preferential affinity of insulin degrading enzyme for insulin leads to insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. However, deficiencies in the function of this protein are associated with Alzheimer’s disease and type 2 diabetes mellitus. However, mutations in IDE have not been discovered to be the cause for these diseases. Insulin degrading enzyme localizes primarily to the cytoplasm but in some cell types, localizes to the extracellular space, peroxisome, cell membrane as well as mitochondrion. Alternative splicing will result in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described however, have not been experimentally verified.
Features of the IDE Monoclonal Antibody
The IDE Monoclonal Antibody has several features. Some of the features it shares with its counterparts, while others are unique to the antibody and distinguish it from others.
The features of IDE Monoclonal Antibody are highlighted below:
- Immunogen – Synthetic Peptide
- Host – Mouse
- Reactivity – Human
- Applications – IF, IHC-p, WB
- Colonality – Monoclonal
- Isotype – Mouse IgG1
- Formulation – liquid solution
- Concentration – 1 mg/ml
- Storage buffer – PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol
Pros of IDE Monoclonal Antibody
The product has been identified to have several pros, especially when compared with its counterparts from other manufacturers. The durability of the product is one of such pros. This is so as it lasts for as long as one year at -20°C from date of shipment if stored under the right condition.
The product’s availability in a liquid solution with flexible dilutions also helps investigators and researchers alike in terms of flexibility.
The antibody is also reported to be affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Cons of IDE Monoclonal Antibody
There is currently no report of negative effects from the use of IDE Monoclonal Antibody. However, it is worth noting that the manufacturers have warned against the use of the product for human or clinical diagnosis, as it is strictly for research purposes only.
The IDE Monoclonal Antibody is another great product from Abbkine Scientific Company Limited. It tends to satisfy the needs of most scientific investigators and researchers.